3B). R526 from the loop among αJ and αI anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at The bottom of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the key chain carbonyl of R413. The tip of your activation phase is stabilized by a hydrogen bond amongst Y454 and E480 from αF. inside the FTF

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